Buscopan (hyoscine butylbromide) in abdominal colic

Hyoscine N-butylbromide (Buscopan®) in the treatment of acute ureteral colic: what is the evidence?

OBJECTIVE To investigate the evidence for the use of hyoscine N-butylbromide (HBB) in the treatment of acute renal colic. METHODS A literature search was performed using the keywords 'hyoscine N-butylbromide', 'ureteral colic', 'spasmolytic', 'anticholinergic' and 'analgesia'. The articles were given the appropriate level of evidence according to the Oxford Centre for Evidence-Based Medicine ...

pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal spasms

Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and in secretory glands. It causes decreased motility of the gastroi...

Studies on the development of rapidly disintegrating hyoscine butylbromide tablets.

The objective of this study was to prepare hyoscine butylbromide (a drug with bitter taste) tablets that can rapidly disintegrate in saliva. The granules were prepared by the extrusion method using aminoalkyl methacrylate copolymers (Eudragit E-100). The drugs dissolved rapidly in medium at pH 1.2 in a dissolution test while none of the drugs dissolved from the granules (% of dissolved < 5%) ev...

Intravenous tenoxicam to treat acute renal colic: comparison with buscopan compositum.

Forty-seven patients with acute renal colic were treated with either tenoxicam 20 mg i.v. or buscopan compositum (hyoscine butylbromide 20 mg and dipyrone 2.5 g) i.v. in a double blind study. Renal colic was diagnosed with use of a general urine examination, intravenous urogram, ultrasonography or voiding of calculus. The severity of symptoms were assessed by a verbal six point scale. Results d...

Effect of hyoscine butylbromide on cervical dilation during labor